Human Macrophage-Activating Factors for Cytotoxicity
نویسندگان
چکیده
منابع مشابه
Human pulmonary macrophage tumor cell cytotoxicity.
In vivo animal studies support the concept that monocytes and macrophages are important in the immune surveillance of oncogenesis and in vitro activated murine macrophages are cytocidal for tumor cells. In this study. we examined human pulmonary macrophage and blood monocyte tumor cell cytotoxicity (a measure of cytostasis and cell kill) and cytocidal activity (cell kill). Three human tumor cel...
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Macrophage Activating Syndrome (MAS) is a life-threatening disease seen in autoimmune diseases including lupus erythematosus, rheumatoid arthritis, Still's disease, polyarteritis nodosa. It is characterized by fever, pancytopenia, liver failure, coagulopathy, and neurologic symptoms and high serum ferritin. A 27 yr. old female patient was admitted in shahid Mostafa Khomeini Hospital (Tehran-Ira...
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BACKGROUND Macrophages play important roles in antitumor immunity, and immunotherapy with the group-specific component protein-derived macrophage-activating factor (GcMAF) has been reported to be effective in patients with various types of cancers. However, in macrophage research, it is important to properly evaluate macrophage activity. MATERIALS AND METHODS U937 macrophages were induced by ...
متن کاملGranulocyte- and granulocyte-macrophage colony-stimulating factors enhance neutrophil cytotoxicity toward HIV-infected cells.
Although the control of retroviral disease in animal systems often involves antibody-dependent cell-mediated cytotoxicity (ADCC), the role of cytotoxic function in human retroviral disorders is uncertain. The ability of the neutrophil to kill HIV-infected targets directed by antiviral antibody was examined. Neutrophils from patients with AIDS killed HIV-infected MOLT-3A cells in a manner equiva...
متن کاملMacrophages Exhibit a Large Repertoire of Activation States via Multiple Mechanisms of Macrophage-activating Factors.
BACKGROUND/AIM Macrophages are important components of human defense systems and consequently key to antitumor immunity. Human-serum macrophage activation factor (serum MAF) can activate macrophages, making it a promising reagent for anticancer therapy. MATERIALS AND METHODS We established four different macrophage subtypes through introduction of different culture conditions to THP-1- and U9...
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ژورنال
عنوان ژورنال: Microbiology and Immunology
سال: 1987
ISSN: 0385-5600
DOI: 10.1111/j.1348-0421.1987.tb03110.x